Series finale: Sean and Christian reflect on their relationship. Ava Moore: Famke Janssen. Brandy Henry: Melanie Griffith. Joan Rivers plays herself.

Julia visits Sean and Christian to share life-changing news, and rejects the advances of both. Meanwhile, a great love from Matt’s past turns up as Matt prepares to make a commitment to someone else; and Liz happily reveals that she’s pregnant. Guest starring Famke Janssen and Melonie Diaz.

As Christian’s existential crisis surfaces, he and Sean do something unusual to boost their sagging practice. Meanwhile, Liz dates a drug-company saleswoman who is separated from her husband. Joan Rivers has a cameo as herself. Annette Wainwright: Joan Van Ark. Lulu Grandiron: Donna Mills. Christian’s Dad: Robert Davi.

Sean and Christian reveal secrets and lay bare past pains as they begin psychotherapy together. Liz and Matt take part as well, and divulge secrets of their own.

Escobar Gallardo’s teen daughter shows up with questions for Sean and Christian about her father, stirring guilty feelings in Sean. Meanwhile, a common cosmetic procedure on an actress goes awry.

Kimber’s mother visits, prompting Christian to suffer a crisis of conscience; complications arise as Sean prepares to travel to Africa; and a patient who had been attacked by a wild animal requires numerous operations.

Following a failed suicide attempt, a new patient seeks facial reconstructive surgery. Meanwhile, Christian and Kimber try something new in bed; and Sean attempts to ease his guilty conscience by performing pro-bono surgery with his humanitarian college friend, Curtis Ryerson (George Newbern). Joel Seabrook: Tim Guinee.

Christian refuses to perform surgery on a model who wants to drastically alter her beauty. Awakening after a decades-long coma, a new patient seeks surgery from Sean in order to regain his lost youth. Kimber redecorates Sean’s new apartment.